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Feature and mechanism of action of the drug Opdivo
Opdivo is available in the form of an infusion for intravenous administration. The active ingredient Nivolumab is a human antibody produced by the cells of the immune system. These antibodies successfully block cancer cells. Each cell of the body has a death program, which is triggered by receptors stimulated by diseases (including neoplasms). Immunoglobulin Opdivo is a blocker of these receptors, that is, in simple words, levels the death program for healthy cells.
Method of administration and dosage of Nivolumab
An oncologist with experience in the treatment of malignant neoplasms should prescribe a course and dosage, as well as administer a medicine. On average, the norm is 3 mg per 1 kg of patient weight. The drug is diluted with a sterile solution of sodium chloride 0.9% or dextrose 5%, bringing to the required volume. The Nivolumab solution must be mixed by gently inverting the bottle, but do not shake. The introduction occurs drip within an hour.
Adverse reactions Opdivo (Opdivo)
Side effects from different body systems can be observed. The most common symptoms: respiratory system - pneumonia, bronchitis, other infections; Gastrointestinal tract - nausea, loss of appetite, cardiovascular system - heart rhythm failure; CNS - headache , dizziness, neuropathy; endocrine system - inflammation of the lymph nodes, dysfunction of the adrenal glands. Dryness of the mucous membrane of the eyes and mouth may appear.
Indications for use
The main purpose of the drug Nivolumab is the treatment of malignant tumors: metastatic melanoma, carcinoma, including inoperable stages. The drug Opdivo prevents the spread and growth of malignant cells in the body. The drug Nivolumab is often prescribed after chemotherapy. The drug Opdivo has a number of contraindications: intolerance to the components; age up to 18; pregnancy and lactation. The drug should be prescribed with caution in the presence of severe autoimmune conditions, severe kidney and liver diseases. The drug is used with extreme caution in the treatment of patients with metastases in the brain. Focus group studies of the drug have shown a high rate of recovery in cancer patients. The drug from Israel is officially approved in Australia, USA, Japan, Canada, European countries. If you intend to buy Opdivo, Nivolumab in an Israeli pharmacy, the price of the drug should be clarified with a consultant.
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